Our genius connect has an intermittent fault saying 'middle man ATL COM Server is not responding' with an option to 'close the program' or 'Wait for the program to respond'. I have to close the program. I then get a genius connect add-in error [the RPC server is unavailable.] and need to restart outlook to continue.

Hello,

are you using MySQL ? If yes please see this topic:
https://support.geniusconnect.com/Posts/t644- 

I see also you are using old version of GeniusConnect edition 5, Please see version 5.0.2.7 (it is the last update in the 5th Edition):

https://www.geniusconnec...om/old-version-download/ 

Thanks, will go through this topic. My version now is Version:601202 Unicode 32 bit target OS Windows 7.Edition:6, Outlook version support: 2000 or higher. Microsoft® Office Outlook® 2016 Click-to-Run (16.0.0.11328). I am trying to update my profile signature with this but it will not save after submitting the edit?

Sorry for that, have updated your profile signature.
If the problem is MySQL Driver, it still applies also for edition 6.